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Free-text
Exposure group
Drug or procedure
Drug major class
Drug class
Include combination exposures
Target
All
ACE inhibitors
ACE inhibitors & Alpha-1 blockers
ACE inhibitors & Angiotensin receptor blockers (ARBs)
ACE inhibitors & Beta blockers
ACE inhibitors & Beta blockers - cardioselective
ACE inhibitors & Beta blockers - cardioselective and vasodilatory
ACE inhibitors & Beta blockers - combined alpha and beta receptor
ACE inhibitors & Beta blockers - noncardioselective
ACE inhibitors & Calcium channel blockers (CCB)
ACE inhibitors & Dihydropyridine calcium channel blockers (dCCB)
ACE inhibitors & Direct vasodilators
ACE inhibitors & Diuretics
ACE inhibitors & Loop diuretics
ACE inhibitors & Non-dihydropyridine calcium channel blockers (ndCCB)
ACE inhibitors & Thiazide or thiazide-like diuretics
Aldosterone antagonist diuretics
Aldosterone antagonist diuretics & Beta blockers - cardioselective
Aldosterone antagonist diuretics & Loop diuretics
Aldosterone antagonist diuretics & Thiazide or thiazide-like diuretics
Alpha-1 blockers
Alpha-1 blockers & Beta blockers
Alpha-1 blockers & Beta blockers - cardioselective
Alpha-1 blockers & Calcium channel blockers (CCB)
Amlodipine
Amlodipine & Benazepril
Amlodipine & Carvedilol
Amlodipine & Clonidine
Amlodipine & Hydralazine
Amlodipine & Labetalol
Amlodipine & Losartan
Amlodipine & Olmesartan
Amlodipine & Ramipril
Angiotensin receptor blockers (ARBs)
Angiotensin receptor blockers (ARBs) & Beta blockers
Angiotensin receptor blockers (ARBs) & Beta blockers - cardioselective
Angiotensin receptor blockers (ARBs) & Beta blockers - combined alpha and beta receptor
Angiotensin receptor blockers (ARBs) & Calcium channel blockers (CCB)
Angiotensin receptor blockers (ARBs) & Dihydropyridine calcium channel blockers (dCCB)
Angiotensin receptor blockers (ARBs) & Diuretics
Angiotensin receptor blockers (ARBs) & Loop diuretics
Angiotensin receptor blockers (ARBs) & Non-dihydropyridine calcium channel blockers (ndCCB)
Angiotensin receptor blockers (ARBs) & Thiazide or thiazide-like diuretics
Atenolol
Atenolol & Amlodipine
Atenolol & Chlorthalidone
Atenolol & Losartan
Azilsartan
Benazepril
Beta blockers
Beta blockers - cardioselective
Beta blockers - cardioselective & Beta blockers - combined alpha and beta receptor
Beta blockers - cardioselective & Dihydropyridine calcium channel blockers (dCCB)
Beta blockers - cardioselective & Direct vasodilators
Beta blockers - cardioselective & Loop diuretics
Beta blockers - cardioselective & Non-dihydropyridine calcium channel blockers (ndCCB)
Beta blockers - cardioselective & Thiazide or thiazide-like diuretics
Beta blockers - cardioselective and vasodilatory
Beta blockers - combined alpha and beta receptor
Beta blockers - combined alpha and beta receptor & Dihydropyridine calcium channel blockers (dCCB)
Beta blockers - combined alpha and beta receptor & Direct vasodilators
Beta blockers - combined alpha and beta receptor & Loop diuretics
Beta blockers - combined alpha and beta receptor & Thiazide or thiazide-like diuretics
Beta blockers - noncardioselective
Beta blockers - noncardioselective & Thiazide or thiazide-like diuretics
Beta blockers & Calcium channel blockers (CCB)
Bisoprolol
Calcium channel blockers (CCB)
Candesartan
Captopril
Carvedilol
Carvedilol & Losartan
Chlorthalidone
Clonidine
Dihydropyridine calcium channel blockers (dCCB)
Dihydropyridine calcium channel blockers (dCCB) & Direct vasodilators
Dihydropyridine calcium channel blockers (dCCB) & Loop diuretics
Dihydropyridine calcium channel blockers (dCCB) & Thiazide or thiazide-like diuretics
Diltiazem
Direct vasodilators
Direct vasodilators & Beta blockers
Direct vasodilators & Calcium channel blockers (CCB)
Direct vasodilators & Diuretics
Direct vasodilators & Loop diuretics
Diuretics
Diuretics & Beta blockers
Diuretics & Calcium channel blockers (CCB)
Doxazosin
Enalapril
Felodipine
Fosinopril
Furosemide
Furosemide & Amlodipine
Furosemide & Atenolol
Furosemide & Carvedilol
Furosemide & Diltiazem
Furosemide & Hydralazine
Furosemide & Lisinopril
Furosemide & Losartan
Furosemide & Metoprolol
Furosemide & Spironolactone
Hydralazine
Hydralazine & Labetalol
Hydrochlorothiazide
Hydrochlorothiazide & Amlodipine
Hydrochlorothiazide & Atenolol
Hydrochlorothiazide & Benazepril
Hydrochlorothiazide & Bisoprolol
Hydrochlorothiazide & Candesartan
Hydrochlorothiazide & Clonidine
Hydrochlorothiazide & Diltiazem
Hydrochlorothiazide & Enalapril
Hydrochlorothiazide & irbesartan
Hydrochlorothiazide & Lisinopril
Hydrochlorothiazide & Losartan
Hydrochlorothiazide & Metoprolol
Hydrochlorothiazide & Olmesartan
Hydrochlorothiazide & Quinapril
Hydrochlorothiazide & Ramipril
Hydrochlorothiazide & Telmisartan
Hydrochlorothiazide & Valsartan
Indapamide
irbesartan
Labetalol
Lisinopril
Lisinopril & Amlodipine
Lisinopril & Atenolol
Lisinopril & Carvedilol
Lisinopril & Chlorthalidone
Lisinopril & Clonidine
Lisinopril & Diltiazem
Lisinopril & Hydralazine
Lisinopril & Labetalol
Lisinopril & Losartan
Lisinopril & Propranolol
Loop diuretics
Loop diuretics & Non-dihydropyridine calcium channel blockers (ndCCB)
Loop diuretics & Thiazide or thiazide-like diuretics
Losartan
Methyldopa
Metoprolol
Metoprolol & Amlodipine
Metoprolol & Clonidine
Metoprolol & Diltiazem
Metoprolol & Enalapril
Metoprolol & Hydralazine
Metoprolol & Labetalol
Metoprolol & Lisinopril
Metoprolol & Losartan
Metoprolol & Ramipril
Metoprolol & Valsartan
Metoprolol & Verapamil
Nadolol
Nebivolol
Nicardipine
Nifedipine
Nifedipine & Labetalol
Non-dihydropyridine calcium channel blockers (ndCCB)
Non-dihydropyridine calcium channel blockers (ndCCB) & Thiazide or thiazide-like diuretics
Olmesartan
Potassium sparing diurectics & Thiazide or thiazide-like diuretics
Prazosin
Propranolol
Quinapril
Ramipril
Ramipril & Bisoprolol
Spironolactone
Telmisartan
Terazosin
Thiazide or thiazide-like diuretics
Torsemide
Triamterene & Hydrochlorothiazide
Valsartan
Valsartan & Amlodipine
Verapamil
Verapamil & Lisinopril
Verapamil & Trandolapril
Comparator
All
ACE inhibitors
ACE inhibitors & Alpha-1 blockers
ACE inhibitors & Angiotensin receptor blockers (ARBs)
ACE inhibitors & Beta blockers
ACE inhibitors & Beta blockers - cardioselective
ACE inhibitors & Beta blockers - cardioselective and vasodilatory
ACE inhibitors & Beta blockers - combined alpha and beta receptor
ACE inhibitors & Beta blockers - noncardioselective
ACE inhibitors & Calcium channel blockers (CCB)
ACE inhibitors & Dihydropyridine calcium channel blockers (dCCB)
ACE inhibitors & Direct vasodilators
ACE inhibitors & Diuretics
ACE inhibitors & Loop diuretics
ACE inhibitors & Non-dihydropyridine calcium channel blockers (ndCCB)
ACE inhibitors & Thiazide or thiazide-like diuretics
Aldosterone antagonist diuretics
Aldosterone antagonist diuretics & Beta blockers - cardioselective
Aldosterone antagonist diuretics & Loop diuretics
Aldosterone antagonist diuretics & Thiazide or thiazide-like diuretics
Alpha-1 blockers
Alpha-1 blockers & Beta blockers
Alpha-1 blockers & Beta blockers - cardioselective
Alpha-1 blockers & Calcium channel blockers (CCB)
Amlodipine
Amlodipine & Benazepril
Amlodipine & Carvedilol
Amlodipine & Clonidine
Amlodipine & Hydralazine
Amlodipine & Labetalol
Amlodipine & Losartan
Amlodipine & Olmesartan
Amlodipine & Ramipril
Angiotensin receptor blockers (ARBs)
Angiotensin receptor blockers (ARBs) & Beta blockers
Angiotensin receptor blockers (ARBs) & Beta blockers - cardioselective
Angiotensin receptor blockers (ARBs) & Beta blockers - combined alpha and beta receptor
Angiotensin receptor blockers (ARBs) & Calcium channel blockers (CCB)
Angiotensin receptor blockers (ARBs) & Dihydropyridine calcium channel blockers (dCCB)
Angiotensin receptor blockers (ARBs) & Diuretics
Angiotensin receptor blockers (ARBs) & Loop diuretics
Angiotensin receptor blockers (ARBs) & Non-dihydropyridine calcium channel blockers (ndCCB)
Angiotensin receptor blockers (ARBs) & Thiazide or thiazide-like diuretics
Atenolol
Atenolol & Amlodipine
Atenolol & Chlorthalidone
Atenolol & Losartan
Azilsartan
Benazepril
Beta blockers
Beta blockers - cardioselective
Beta blockers - cardioselective & Beta blockers - combined alpha and beta receptor
Beta blockers - cardioselective & Dihydropyridine calcium channel blockers (dCCB)
Beta blockers - cardioselective & Direct vasodilators
Beta blockers - cardioselective & Loop diuretics
Beta blockers - cardioselective & Non-dihydropyridine calcium channel blockers (ndCCB)
Beta blockers - cardioselective & Thiazide or thiazide-like diuretics
Beta blockers - cardioselective and vasodilatory
Beta blockers - combined alpha and beta receptor
Beta blockers - combined alpha and beta receptor & Dihydropyridine calcium channel blockers (dCCB)
Beta blockers - combined alpha and beta receptor & Direct vasodilators
Beta blockers - combined alpha and beta receptor & Loop diuretics
Beta blockers - combined alpha and beta receptor & Thiazide or thiazide-like diuretics
Beta blockers - noncardioselective
Beta blockers - noncardioselective & Thiazide or thiazide-like diuretics
Beta blockers & Calcium channel blockers (CCB)
Bisoprolol
Calcium channel blockers (CCB)
Candesartan
Captopril
Carvedilol
Carvedilol & Losartan
Chlorthalidone
Clonidine
Dihydropyridine calcium channel blockers (dCCB)
Dihydropyridine calcium channel blockers (dCCB) & Direct vasodilators
Dihydropyridine calcium channel blockers (dCCB) & Loop diuretics
Dihydropyridine calcium channel blockers (dCCB) & Thiazide or thiazide-like diuretics
Diltiazem
Direct vasodilators
Direct vasodilators & Beta blockers
Direct vasodilators & Calcium channel blockers (CCB)
Direct vasodilators & Diuretics
Direct vasodilators & Loop diuretics
Diuretics
Diuretics & Beta blockers
Diuretics & Calcium channel blockers (CCB)
Doxazosin
Enalapril
Felodipine
Fosinopril
Furosemide
Furosemide & Amlodipine
Furosemide & Atenolol
Furosemide & Carvedilol
Furosemide & Diltiazem
Furosemide & Hydralazine
Furosemide & Lisinopril
Furosemide & Losartan
Furosemide & Metoprolol
Furosemide & Spironolactone
Hydralazine
Hydralazine & Labetalol
Hydrochlorothiazide
Hydrochlorothiazide & Amlodipine
Hydrochlorothiazide & Atenolol
Hydrochlorothiazide & Benazepril
Hydrochlorothiazide & Bisoprolol
Hydrochlorothiazide & Candesartan
Hydrochlorothiazide & Clonidine
Hydrochlorothiazide & Diltiazem
Hydrochlorothiazide & Enalapril
Hydrochlorothiazide & irbesartan
Hydrochlorothiazide & Lisinopril
Hydrochlorothiazide & Losartan
Hydrochlorothiazide & Metoprolol
Hydrochlorothiazide & Olmesartan
Hydrochlorothiazide & Quinapril
Hydrochlorothiazide & Ramipril
Hydrochlorothiazide & Telmisartan
Hydrochlorothiazide & Valsartan
Indapamide
irbesartan
Labetalol
Lisinopril
Lisinopril & Amlodipine
Lisinopril & Atenolol
Lisinopril & Carvedilol
Lisinopril & Chlorthalidone
Lisinopril & Clonidine
Lisinopril & Diltiazem
Lisinopril & Hydralazine
Lisinopril & Labetalol
Lisinopril & Losartan
Lisinopril & Propranolol
Loop diuretics
Loop diuretics & Non-dihydropyridine calcium channel blockers (ndCCB)
Loop diuretics & Thiazide or thiazide-like diuretics
Losartan
Methyldopa
Metoprolol
Metoprolol & Amlodipine
Metoprolol & Clonidine
Metoprolol & Diltiazem
Metoprolol & Enalapril
Metoprolol & Hydralazine
Metoprolol & Labetalol
Metoprolol & Lisinopril
Metoprolol & Losartan
Metoprolol & Ramipril
Metoprolol & Valsartan
Metoprolol & Verapamil
Nadolol
Nebivolol
Nicardipine
Nifedipine
Nifedipine & Labetalol
Non-dihydropyridine calcium channel blockers (ndCCB)
Non-dihydropyridine calcium channel blockers (ndCCB) & Thiazide or thiazide-like diuretics
Olmesartan
Potassium sparing diurectics & Thiazide or thiazide-like diuretics
Prazosin
Propranolol
Quinapril
Ramipril
Ramipril & Bisoprolol
Spironolactone
Telmisartan
Terazosin
Thiazide or thiazide-like diuretics
Torsemide
Triamterene & Hydrochlorothiazide
Valsartan
Valsartan & Amlodipine
Verapamil
Verapamil & Lisinopril
Verapamil & Trandolapril
Outcome
All
Abdominal pain
Abnormal weight gain
Abnormal weight loss
Acute myocardial infarction
Acute pancreatitis
Acute renal failure
All-cause mortality
Anaphylactoid reaction
Anemia
Angioedema
Anxiety
Bradycardia
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular-related mortality
Chest pain or angina
Chronic kidney disease
Cough
Decreased libido
Dementia
Depression
Diarrhea
End stage renal disease
Fall
Gastrointestinal bleeding
Gout
Headache
Heart failure
Hemorrhagic stroke
Hepatic failure
Hospitalization with heart failure
Hospitalization with preinfarction syndrome
Hyperkalemia
Hypokalemia
Hypomagnesemia
Hyponatremia
Hypotension
Impotence
Ischemic stroke
Malignant neoplasm
Measured renal dysfunction
Nausea
Neutropenia or agranulocytosis
Rash
Rhabdomyolysis
Stroke
Sudden cardiac death
Syncope
Thrombocytopenia
Transient ischemic attack
Type 2 diabetes mellitus
Vasculitis
Venous thromboembolic events
Vertigo
Vomiting
Database
All
CCAE
CUMC
IMSG
JMDC
MDCD
MDCR
NHIS_NSC
Optum
Panther
Search
Search
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LegendMed Central
LegendMed Central